Welcome to “A Dose of Reality”, the podcast where we infuse insight, laughter, and practical wisdom into the world of clinical leadership and career development. Hosted by Charles Spence, each episode offers a deep dive into the challenges and triumphs of clinical leadership, providing listeners with meaningful conversations, career insights, and a dose of inspiration to navigate their professional journeys.
Whether you're a director, a C-level executive, or a clinical researcher in oncology bio-techs, this podcast is designed to empower you with the knowledge and tools needed to excel in your field.
So, visit our website at www.discera-search.com, and tune in to A Dose of Reality for your prescription of career wisdom, leadership insights, and a healthy dose of laughter.
Subscribe now and join us on the journey to becoming global clinical leaders!
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Sven Van den Berghe, CEO of Pantera on Overpromises in Isotope Marketing, Why Culture is the Company, and Discussions in RLT Development (00:27:26)
In this episode, I talked with Sven Van den Berghe, CEO of Pantera, about his 25+ years in nuclear physics, from his early days at the Belgian Nuclear Research Center to stepping into the high-stakes world of radioisotope production.Sven speaks openly about the toughest move of his career: leaving the safety of a government research institute to run a startup where pressure, governance disputes, and fundraising could make or break the company. He explains why independent boards are essential, how culture must be defined from day one, and why money and trust suddenly matter a lot more when you’re no longer in a state-funded environment.He also shared the fine line between science and marketing in radiopharmaceuticals—the misleading claims, the half-truths about isotope supply, and how exaggeration risks turning investors and the public away from the whole field. Sven also gives a clear picture of Pantera’s mission to expand actinium-225 production, what real diversity in a team looks like, and why letting people go quickly can be the fairest option for everyone.We also spoke about Sven’s view on recruiters—the practices that cross the line and what still makes collaborations worthwhile.(Find out more in the episode.)Here’s What You’re In ForGovernance clashes with corporate founders in Pantera’s early yearsBuilding a leadership team that complements each other’s strengthsSven’s frustrations with recruiter behaviorTimestamps01:06 – Choosing a PhD and landing at the Belgian Nuclear Research Center03:05 – The hardest step: leaving government research for startup life04:49 – Governance disputes and the need for independent boards06:32 – Lessons learned: business plans, money, and building trust in leadership teams08:24 – Culture as the foundation of Pantera’s identity09:02 – How hype and half-truths distort isotope marketing10:50 – Why reliability, cost, and scale matter more than technical ability12:13 – The danger of running down competitor isotopes14:00 – What Pantera is building: actinium-225 supply today and long-term plans22:22 – Hiring and why letting people go quickly can be the right call24:08 – Sven’s frustrations with recruiter behaviorAbout SvenSven Van den Berghe is the CEO of PanTera, a company that aims to expand the supply of medical isotopes for cancer therapies. With a background in physics and a PhD in materials science, Sven spent more than two decades at the Belgian Nuclear Research Center (SCK CEN), where he rose through the ranks to become Institute Director. In 2021, he made the bold move from a secure government institute to leading a biotech startup—an inflection point he calls one of the hardest, but most rewarding, decisions of his career.Throughout his career, Sven has combined deep technical expertise in nuclear research with leadership in complex organizations. Today, he leads Pantera in its mission to expand the global supply of medical isotopes, drawing on his background in science, governance, and international collaboration. Connect with Sven:LinkedIn: https://www.linkedin.com/in/svenvdberghe/ Website: https://pantera-life.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in...
Catello Somma, Partner at Seroba on Working in VC, Non-Linear Biotech Careers, and advice for those seeking VC careers (00:21:47)
In this episode, I talked with Catello Somma, Partner at Seroba, to learn about his nonlinear journey from academia and biopharma into venture capital—and the realities behind building funds, backing biotech founders, and surviving industry downturns.Catello shares the turning points that shaped his career: walking away from his PhD to get closer to patients, breaking into VC after years in biotech operations, and the hard decision to leave a fund when partnership opportunities weren’t on the table. He also gives an insider’s view on what people get wrong about venture capital—the pressure of fundraising cycles, the competition for partnership seats, and why the job is far from the traditional perception of “writing checks from a couch.”And to round things off, he takes on some quick-fire questions, from his daily coffee intake to the advice he wishes he’d heard earlier in his career.(Find out more in the episode.)Here’s What You’re In ForThe skills biotech professionals often lack when they first enter VCThe hard truth about career progression in VC—why few ever make partnerHow the biotech funding downturn is reshaping investor behaviorTimestamps1:45 – Leaving academia, dropping a PhD, and first steps into industry4:02 – Pros and cons of entering VC from biotech vs finance-only backgrounds8:13 – What differentiates Seroba: flat structure, collegiality, and no egos10:02 – How the biotech recession and closed IPO window reshaped strategies13:11 – The biggest misconceptions about venture capital work16:14 – The insecurity of VC careers: five-year fund cycles and job risk17:29 – Hard lessons: breaking into VC and walking away when promotion wasn’t possible19:35 – Quick-fire round: coffee habits, books, family life, funniest dinner with KevinAbout CatelloCatello Somma is a Partner at ROA Ventures, where he invests in early-stage life science companies across Europe and North America. His path into venture wasn’t straightforward: after leaving a PhD program to get closer to patients, he built his career in CROs and biotech operations, later completing an MBA to bridge the gap between science and finance. Before joining Seroba, Catello worked on both sides of the biotech ecosystem, from building operational teams to structuring deals. Currently, he focuses on supporting founders through the toughest parts of the journey: scaling companies, navigating funding cycles, and preparing for exits. Known for his pragmatic approach and emphasis on culture, Catello brings a long-term mindset to venture—balancing the pressures of short-term market shifts with the resilience needed to build enduring biotech businesses.Connect with Catello:LinkedIn: https://www.linkedin.com/in/catellosomma/ Website: https://serobavc.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: <a href="https://www.linkedin.com/in/charles-spence-clinical/"...
Kevin N. Heller, MD, Chief Medical Officer and Advisor to Funds and VCs, on Culture Shifts, Tough Lessons In Leadership, And The Reality Of Biotech Fundraising (00:29:36)
In this episode, I talked with Dr. Kevin Heller, former biotech CMO and now advisor to VCs and funds, who’s built his career at the intersection of science, leadership, and investment. Kevin started out as a pediatric hematologist–oncologist before joining BMS, where he worked on one of the first checkpoint inhibitor programs. Since then, he’s held senior roles across biotech and now works closely with companies and investors on strategy.Kevin opened up about the habits that nearly held him back early in his career, how a colleague’s honest feedback changed the way he leads, and why the quiet moments in meetings often say more about culture than the loud ones.He also shared about today’s funding climate—why raising money feels tougher than ever, what investors really look for, and why every company needs a clear plan for when things don’t go as expected. And outside of biotech, Kevin’s focus is on mentoring the next generation of scientists through the Society for Science, an organization he’s been deeply involved with for years.Here’s What You’re In ForThe subtle warning signs of a weak culture (and why silence is the biggest one)The kind of questions investors ask now that many companies aren’t ready forHow mentoring young scientists through the Society for Science has become Kevin’s way of giving backTimestamps00:58 – How Kevin moved from academia into industry06:00 – The colleague who bluntly told him to be quiet10:20 – What Kevin has seen change in biotech fundraising over the past few years12:34 – The advice he gives to early-stage companies heading into investor meetings16:15 – What most outsiders don’t realize about being on the investment side17:54 – What “culture” actually means to him, and why bad leadership kills it20:14 – The subtle early signs of a broken culture: silence in meetings26:48 – Kevin’s involvement with the Society for Science and mentoring future scientistsAbout KevinKevin Heller is a former biotech CMO and a current advisor to funds and VCs. He serves as Investment Team Advisor at an equity fund investing in biotech. He is a Pediatric Hematologist/Oncologist, and began his career at BMS where he contributed to the development of YUR-VOY.He has held CMO roles at several biotech companies, worked on numerous early-stage programs (including at Incyte), and continues to influence the field through his advisory roles.Kevin serves as a mentor, judge, and council member of Society for Science, a nonprofit that promotes science literacy and runs major student science fairs worldwide, in his way of giving back to the mentors who guided him early in his career. For him, it’s about inspiring the next generation to see science as something they can own and shape.Connect with Kevin:LinkedIn: https://www.linkedin.com/in/kevin-n-heller-8bbb985/ Society for Science:https://www.societyforscience.org/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment, I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East
Carl Deutsch, CSO at NBE Therapeutics in Non-Linear Careers, Age Bias, and Building Great Teams (00:37:28)
In this episode, I talked with Dr. Carl Deutsch, Chief Scientific Officer at NBE Therapeutics, where he shared about his path from chemistry into pharma and the lessons he’s learned along the way. Carl recalls how difficult it was to secure his first role when jobs were scarce, the pressure of multiple interview rounds, and how a non-linear career path led to both opportunities and doubts about fitting the expected mold.He discussed the differences between biotech and big pharma cultures, what it means to lead in a “cultural sandwich” role, and why accountability and agility look different depending on the environment. Carl also spoke about age bias in hiring, the importance of curiosity during interviews, and the kind of toxic hiring process that made him withdraw his application early in his career.He explained why he looks for “band members” instead of “rock stars” when building teams, how character matters more than buzzwords or tick-box credentials, and why blinded CVs often miss the real story behind a candidate. And, in a lighter moment, Carl answered a series of quick-fire questions—from his habit of quoting movies, to the kinds of conversations he avoids, to the advice he’d give to someone starting out in the industry.Here’s What You’re In ForThe benefits and challenges of a non-linear career pathWhy networking often matters more than a “tick-box” CVWhy blinded CVs fail to capture the real story behind a candidateTimestamps02:20 – Scarcity and the First Job Hunt05:10 – Non-Linear Careers and Self-Doubt07:00 – The CV Tick-Box Trap14:00 – Leading in a Cultural Sandwich17:00 – What Biotech Culture Really Means20:00 – Hiring for Accountability and Fit23:00 – Age Bias in Pharma Hiring30:00 – Band Members vs Rock Stars in Building a Team32:00 – Why Blinded CVs Miss the Story33:30 – Quick-Fire: Movie Quotes, Habits, and Career AdviceAbout CarlDr. Carl Deutsch, Chief Scientific Officer at NBE Therapeutics. A chemist by training, Carl earned his PhD in Dortmund, Germany, and went on to broaden his scientific horizons in the U.S. and Japan. He later added a business edge to his profile with an MBA from Mannheim Business School and ESSEC Paris.Carl played a key role in the development of Mercks first in-house antibody-drug conjugate, M9140, and also helped drive innovation as an intrapreneur, launching an award-winning project under Merck Life Science. Since 2022, he has been leading scientific strategy at NBE Therapeutics.Outside the lab, Carl has a creative side, he once took the stage as a member of an acting group and joining wild podcasts like mine.Connect with Carl:LinkedIn: https://www.linkedin.com/in/carl-deutsch-phd-mba-82ba28168/ NBE Therapeutics: https://nbe-therapeutics.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment, I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: <a...
Aleksandra Filipovic, Chief Medical Officer at Gallop Oncology on Perfectionism, Intuition, and the Risk of Building Unsafe Teams (00:34:49)
In this episode, I talked with Dr. Aleksandra Filipovic, CMO at Gallop Oncology, a biotech developing first-in-class galectin-9 antibodies for solid tumors and blood cancers. We talked about how perfectionism shaped her early leadership, and what it took to undo it. She shared her take on hiring by “gut feel,” why that can quietly reinforce bias, and what she looks for instead.Aleksandra also opened up about her childhood—growing up with two cancer-researcher parents, skipping school to attend medical conferences—and how that path eventually led her to leave Serbia with a six-month visa and no real plan. That risk turned into a 20-year career in the UK, and a leadership journey she never could have mapped out.She once brought a pipette to school for show and tell. These days, she reads nervous systems before resumes, believes leadership is about repair—not perfection—and says her job is to “love a drug into existence.”Later this year, Aleksandra will be leading a workshop at the Society of Integrative Oncology Annual Meeting in Boston on October 27, 2025, alongside her colleagues Dr. Anna Yusim and Dr. Steve Bierman. The session, “Creating a New Kind of Intelligence in Oncology Practice” will explore neuro-somatic intelligence, noetic medicine, and mental health in oncology and biotech. CME credits and a full training curriculum will be provided. More information below.Here’s what you’re in for:Why she’s grateful her career didn’t go according to planWhy hiring based on “gut feeling” can lead to prejudice if you’re not carefulHow perfectionism quietly seeps into leadershipTimestamps:02:00 Childhood in a Cancer-Obsessed Family06:30 Why She Left Serbia With No Job and No Plan09:00 When Your Career Goes “Wrong”, and It’s the Best Thing That Happens16:45 Interview Advice: “Don’t Perform—Be Honest”21:30 What Falls Apart When Hiring Goes Wrong23:30 The Danger of “Gut Feel” in Leadership Hiring33:00 What It Feels Like When Your Childhood Perfectionism Takes Over at Work36:00 How She Regulates Herself as a Leader—and Teaches Her Team To Do the Same39:00 The Workshop: Neurosomatic Tools for Oncology ProfessionalsAbout Aleksandra:Dr. Aleksandra Filipovic is the Chief Medical Officer at Gallop Oncology, where she leads oncology asset sourcing and preclinical to clinical development strategy. With a background as a clinical oncologist and a PhD in Cancer cell biology its safe to say she knows a lot about this area. Prior to joining Gallop, Aleks still acts as the head of oncology for PureTech health and prior to this she was with BMS and also consulted for Astrazeneca. She is a practicing clinician from Imperial College London, sits on the board of a global oncology educational platform sharing progress in cancer care and hosts a podcast “Into the Body” with Dr. Alex for OncoDaily. She practices applied neuro-somatic-intelligence with cancer patients and applies these same principles in biotech leadership. Connect with Aleksandra:Linkedin: https://www.linkedin.com/in/aleksandra-filipovic-md-ph-d-0b63441b/ From Our Guest — Upcoming Workshop for Oncology ProfessionalsAre you in the oncology field, feeling the weight of burnout and seeking ways to enhance your patient care within the limited time you have in clinic? Reconnect to the core of your work with our upcoming workshop.Join Dr. Anna Yusim, @SteveBierman from Andrew Weil Center for Integrative Medicine, and myself for an impactful session in Boston on October 27th from 8-9:45AM. This workshop is a part of the Society for Integrative Oncology...
Heidi Wang, CEO at OBI Pharma & Chairwoman at OBIGEN Pharma on Losing Her Father to Cancer, Hiring Without Humility, and Building a Culture That Lasts (00:27:46)
In this episode, I talked with Heidi Wang, CEO of OBI Pharma and Chair of OBIGEN, who shares her powerful story, from losing her father to cancer while raising two children, to leading oncology drug approvals at BMS, and now, building out a bold ADC pipeline in biotech.Heidi opens up about the pressures of leading during personal tragedy, how BMS supported her through it, and why she now builds teams around values like authenticity and innovation. This episode is equal parts personal and professional, offering rare insight into what true leadership looks like, especially in biotech.Here’s what you’re in for:Why staying at BMS for 30 years wasn’t plannedA behind-the-scenes look at OBI’s antibody-drug conjugate (ADC) platformWhat authenticity looks like in interviews (with stories from Stanford PhDs to Shanghai branding workshops)TMI Segment:Coffee intake? Hint: Usual number for a regular coffee drinkerHidden gem in Taiwan? Hint: You see it every day, do not think too much.Favorite book? Hint: It has something to do with “Hidden”Most grateful for? Hint: POV of a good leader Can’t guess the answer? Listen to the episode to find out.Timestamps:01:56 – How Losing Her Father to Cancer Shaped Her Life's Work04:53 – “It Was Only Chemotherapy Back Then”—Facing the Limits of Treatment06:34 – What 10,000 Stomach Cancer Patients Meant to Her08:45 – Would She Have Quit BMS If They Didn’t Support Her? 10:21 – Why She Joined OBI and Her Vision for ADC Innovation13:34 – What She Really Looks For When Hiring15:34 – The Arrogance Trap in Interviews17:16 – Humility vs. Branding: Hiring Across US and Asian Cultures20:20 – The Worst Outcome of Rushed Hiring22:50 – When You Don’t Need a Hire25:40 – Quickfire QuestionsAbout HeidiDr. Heidi Wang is the CEO of O-B-I Pharma and Chairman of OBIGen, a biotech specializing in oncology. With nearly 30 years of experience in drug development and regulatory affairs, Heidi has led approvals for immuno-oncology and antiviral drugs globally. O-B-I Pharma has a unique pipeline of ADCs and cancer immunotherapies of which we will learn during the episode.She holds a Ph.D. in molecular biology and completed postdoctoral training in cancer biology. She also mentors and teaches extensively - rarely accepting payment personally and always donating to charity instead, love that. She has kindly donated her time here, welcome. Connect with Heidi:LinkedIn: https://www.linkedin.com/in/heidiwang/ OBI Pharma: https://www.obipharma.com/ OBIGEN: https://www.obigenpharma.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: <a href="https://www.linkedin.com/in/charles-spence-clinical/" rel="noopener noreferrer"...
András Strassz, MD, MBA, CMO at Heidelberg Pharma – Career Crossroads, Recruiting, and Culture Fit Over CVs (00:38:03)
In this episode, I talked with Dr. András Strassz, Chief Medical Officer at Heidelberg Pharma, to hear about his two decades of leadership in oncology drug development—and the often-overlooked realities behind building teams, designing clinical trials, and making biotech work.András opens up about key moments in his career, including the personal crisis that almost forced him to leave the industry, the turning point when he stepped into his CMO role, and what it really takes to develop first-in-class ADCs with novel payloads.We also dive deep into industry-wide mistakes—why promising clinical programs still fail because of poor design, how pressure and under-resourcing distort decision-making, and why senior leadership continues to overlook culture fit when hiring.András also shares behind-the-scenes insights into Heidelberg’s development of amanitin-based ADCs, what makes their team culture unique, and why “good enough” just isn’t good enough when you’re trying to build something from scratch.(Find out more in the episode.)Here’s What You’re In ForWhy culture alignment should outweigh credentials when building teamsHow to spot red flags in hiring—even before the offer stageWhat good leadership looks like in biotech—and what it never forgetsTimestamps02:18 – Why he left clinical practice and how he got his first pharma job at J&J05:38 – Career highlights: relocating from Hungary and becoming CMO09:09 – Career low point: near job loss during relocation and how he handled it11:01 – Burnout in his first role and the health consequences of overwork13:38 – Overview of Heidelberg Pharma’s ADC platform 15:58 – What defines the people and culture at Heidelberg18:51 – Biggest industry mistakes: bad study design, rushed decisions, outdated models26:00 – Hiring reflections: CV vs culture fit, and how interviews often misleadAbout AndrásDr. András Strassz is the Chief Medical Officer of Heidelberg Pharma, a clinical stage biopharmaceutical company specializing in antibody-drug conjugates (ADCs) for targeted cancer treatment. András specializes in early clinical development, focusing on oncology and hematological oncology. He has experience working in both Big Pharma, namely JnJ, Amgen, Novartis, and Biotechs - Polyphor, Affimed, and his current company, Heidelberg Pharma across three countries: Hungary, Germany, and Switzerland. Outside his professional stint, his hobbies are DIY, hiking, and cooking. We have know each other for a while now, always appreciated András honesty, humour and insights and he is here to join me today - welcome.Connect with AndrásLinkedIn: https://www.linkedin.com/in/András-strassz-md-mba-a03a1147/ Heidelberg Pharma: https://heidelberg-pharma.com/en/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: <a...
Steven Katz, MD, CMO and SVP of Translational Science for Shinobi Therapeutics & Professor of Surgery at Brown University - Hiring Without Regret, Team Mismatches, and the Cost of Playing It Safe in Biotech (00:36:03)
In this episode, I talked with Dr. Steven Katz, CMO and SVP of Translational Science for Shinobi Therapeutics, a biotech company pioneering off-the-shelf immune-evasive IPSC-derived cell therapies, and Professor of Surgery at Brown University. We get into why technical skills alone won’t cut it—and how the wrong hire, even if they look great on paper, can quietly derail an entire team. We talk about the pressure to stick with “proven” endpoints (even when they don’t fit the science), the temptation to play it safe, and how a quiet sense of nihilism can creep into teams when things aren’t going right. We also dig into what it’s really like managing a global biotech team, and how to make it work without losing your mind.Steven is a trained surgical oncologist and associate professor at Brown University, Steven has spent his career helping patients with solid tumors—from removing liver and pancreatic cancers in the OR to pushing the limits of immunotherapy in biotech. He was previously CMO at Trius Life Sciences.Here’s what you’re in for:What happens when you don’t clearly define what you’re hiring forHow bad hires can quietly fracture entire clinical programsWhy the “safe” development plan isn’t always the smartest—and when to take the risk anywayTMI: Things You Didn’t Know About StevenLoves tennis, history, and TRX workoutsFavorite thing in London? The West End theater scene (avoid: kids on Netflix!)Timestamps:04:06 – Lessons from surgery that shaped his biotech career08:35 – Advice to surgeons and doctors considering a move to biotech13:20 – Why IPSC is so promising for oncology and autoimmune disease17:00 – Culture clash or culture strength? Japan–US dynamics at Shinobi22:30 – When internal alignment falls apart24:35 – Playing it safe vs. doing what’s right26:19 – Common mistakes Steven still sees in biotech30:15 – The problem with drug delivery in solid tumors31:00 – Best and worst experiences with recruiters33:08 – What happens when you hire the wrong person34:46 – Final question: What is Steven most grateful for in his careerAbout StevenDr. Steven Katz is the CMO and SVP of Translational Science for Shinobi Therapeutics for Shinobi Therapeutics, a biotech developing off-the-shelf, immune-evasive, iPSC-derived cell therapies, and Professor of Surgery at Brown University. He has dedicated his career to helping patients with solid tumors in the operating room and developing novel immunotherapy solutions for those beyond the reach of current standard-of-care options. Outside of his professional stint, he spends time with his children, doing TRX workouts, playing tennis, reading history and of course joining me on this podcast - welcome.Connect with Steven:LinkedIn: https://www.linkedin.com/in/katz-steve/ Website: https://www.shinobitx.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and...
Christian Mueller, CDO at Immutep on Career Crossroads, Culture Missteps, and the Recruitment Disconnect in Biotech (00:35:38)
In this episode, I talked with Christian Mueller, Chief Development Officer at Immutep. Christian’s path into biotech wasn’t exactly planned—from summarizing VC business plans during his studies to becoming a driving force behind the world’s first Claudin 18.2-directed antibody.We talked about the wins and the setbacks: from finally securing Pembrolizumab supply after years of rejections, to those painful moments when you give your all to a project, and still feel unseen. Christian also opened up about hiring, leadership, and what makes a biotech team truly work (or fall apart). He shared why Immutep has gone all-in on LAG-3, what makes their international culture different from most, and why knowing your weaknesses might just be the most underrated leadership skill.And to wrap things up, we threw in a few quickfire questions, from the book he’s reading (featuring octopuses!) to what he tries to do every single day to stay sharp.Here’s what you’re in for:The red flag that made Christian walk away from a companyWhy great hiring is about cultural fit, not just perfect CVsWhat small biotechs misunderstand most about recruitmentTimestamps:01:54 – From Economics to Biotech: How VC Summaries Led to Drug Development07:41 – Career Lows: Feeling Undervalued and Facing a Regulatory Near-Shutdown13:48 – Why LAG-3? The Science and Conviction Behind Immutep’s Strategy14:34 – Inside Immutep: Low-Ego Culture, Fast Decisions, and Argument-Driven Thinking17:00 – Hiring With Humility: The Culture Fit That Matters Most22:47 – Cultural Fit Over Credentials: What Hiring Managers Really Want33:44 – Quickfire Questions: Books, Octopuses, and Trying New ThingsAbout ChristianChristian Mueller currently serves as the Chief Development Officer at Immutep, where he has been instrumental in advancing the company's lead compound, Efti, from Phase I through to Phase III clinical trials. Prior to his tenure at Immutep, Christian led the clinical development of Zolbetuximab, the first-ever CLDN18.2-directed antibody. Christian brings a unique multidisciplinary mindset to his work, describing himself as a “translator” between different scientific and operational domains. Outside of work, he is a lifelong basketball fan and enjoys spending time in natureConnect with ChristianLinkedIn: https://www.linkedin.com/in/christian-mueller-05199481/ Immutep: https://www.immutep.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/ Website: https://www.discera-search.com/ Opinions and comments expressed by the guest do not represent the company and are...
Kirsty Crame-van Nierop, Director of Shiaba Consulting, Specialist on Clinical Drug Development, in Broken Hiring Cycles, IND Wins, and Surviving Biotech Burnout (00:34:09)
In this episode, I talked with Kirsty Crame-van Nierop, Director of Shiaba Consulting, Specialist in Clinical Drug Development. Kirsty shares her career journey, including her transition from aspiring vascular surgeon to a leader in personalized targeted therapies. We went over her key career highlights, and the challenges faced during COVID, and she gave valuable career bits of advice. Kirsty gave insights on the importance of hiring the right people in clinical development, the balance between using consultants and in-house expertise, the cultural fit in hiring, and her experiences in the job search process, highlighting the importance of communication and feedback in recruitment.Here’s what you’re in for:The problem with "unicorn" hiring expectations.Why the best hiring decisions often begin three to six months too late.When outsourcing fails: why early-stage biotech still needs in-house decision-makers.Timestamps01:56 From Vascular Surgery Dreams to Unexpected Beginnings04:41 The High of an IND Win, and the Low of Leading Through Lockdown07:25 The Career Advice That Changed Her Trajectory09:34 Why Early Decisions Make or Break Biotech17:52 In-House vs. Outsourced Roles19:15 “What Do We Actually Need?” – A Biotech Hiring Dilemma28:22 The Harsh Reality Behind Biotech Applications32:36 The Value of Long-Term Professional RelationshipsAbout KirstyKirsty Crame is a seasoned medical doctor of over 12 years of experience in drug development. She got her MD in Amsterdam and since then has worked across therapeutic areas, diabetes, cancer, et cetera. But most, if not all, of her clinical development career, has been using personalized targeted therapies to find new cures to cancer. Outside of her professional life, Kirsty is a dedicated mother of two boys. She brings the same energy and discipline from the clinic to the field. She's an avid field hockey player and embraces an active lifestyle that keeps her balanced and thriving. Kirsty and I know each other as she was a candidate and then client of mine at Medigene.Connect with Kirsty:LinkedIn: https://www.linkedin.com/in/kirsty-crame-van-nierop-418b0b38/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/ Website: https://www.discera-search.com/ Opinions and comments expressed by the guest do not represent the company and are fully their own.
Bernhardt Zeiher, M.D. Member of the board of directors for Entrada Therapeutics, Amylyx Pharmaceuticals, and Abeona Therapeutics on Lessons from Leading a Global Development Organization (00:34:06)
In this episode, I talked with Dr. Bernhardt (Bernie) Zeiher, where he shares key lessons and personal insights from over 25 years in pharmaceutical drug development. Bernie discusses pivotal career moments, including the emotional impact of halting a promising Phase III trial for ARDS, as well as successes such as achieving six drug approvals at Astellas. He emphasizes the critical role of data-driven decision-making, thoughtful hiring, and proactive leadership in managing clinical programs. Bernie also provides candid reflections on common organizational challenges, particularly the damaging effects of poorly executed reorganizations and layoffs. Throughout the conversation, he underscores the importance of fostering a strong, cohesive team culture, and the necessity of continuous learning and adaptation in pharma leadership.Bernie also answers some quickfire personal questions: daily coffee habit? Unusual food did Bernie try for the first time recently? Who were the mentors that shaped Bernie’s career the most?(Find out more in the episode.)Here’s What You’re In ForHow data shapes tough go/no-go decisions in drug development.Understanding and avoiding common mistakes during organizational restructuring.Deciding the right moment to transition from part-time consultants to dedicated in-house expertise.Timestamps01:10 Career beginnings and transition from pulmonology to pharma03:35 Emotional setbacks from clinical trial failures09:00 Factors behind Astellas' multiple drug approvals12:20 Common pitfalls organizations face during restructuring and reorganizations16:10 Timing the shift from consultants to dedicated internal clinical leadership19:40 How Bernie assesses culture fit and hiring red flags26:00 Quick insights and personal reflectionsAbout BernieDr. Bernhardt Zeiher is a Member of the board of directors for Entrada Therapeutics, Amylyx Pharmaceuticals, and Abeona Therapeutics. Dr. Zeiher is a physician specializing in pulmonary and critical care medicine with over 25 years of experience in drug development. He played a key role in securing approval for CRESEMBA (isavuconazole) for invasive aspergillosis and mucormycosis. As Head of Development and later Chief Medical Officer at Astellas, led the organization through one of its most productive periods, overseeing six late-phase development products.Connect with Bernie:LinkedIn: https://www.linkedin.com/in/bernhardtzeiher/ Entrada Therapeutics: https://www.entradatx.com/ Amylyx Pharmaceuticals: https://www.amylyx.com/ Abeona Therapeutics: https://www.abeonatherapeutics.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: <a...
Ilya Gipp, CMO at GE Healthcare – Imaging’s Role in Oncology, Hiring Lessons, and How Culture Really Works (00:38:18)
In this episode, I talked with Dr. Ilya Gipp, Chief Medical Officer at GE Healthcare, where he shares lessons from a career spent at the intersection of clinical medicine and medtech leadership. He talks about his journey from practicing radiologist to leading GE’s oncology strategy, the emotional highs of building impactful programs, and the frustrations of pushing forward ideas when teams aren't aligned. Ilya also reflects on the evolving role of imaging in cancer care, and why true innovation means making technology not just better, but more accessible.He also discussed hiring and leadership: how to time a hire before it’s too late, the danger of relying on org charts, and why horizontal communication matters more than hierarchy. Ilya opens up about culture, team building, and what it really means to feel valued at work. He closes with a look ahead, sharing his excitement for global initiatives aimed at expanding cancer care in underserved regions.In this episode, we cover:Why being both a doctor and an innovator became Ilya’s calling.A candid story of hiring too late—and what it costs him.Why “escalation” is a sign something’s already broken.Timestamps:00:54 Travel and Work-Life Balance02:08 Career Journey and Passion for Technology04:22 Highs and Lows in the Medical Field08:38 The Role of GE Healthcare in Oncology16:46 Company Culture, Hiring Insights, and Strategies30:40 Quickfire Questions About IlyaDr. Ilya Gipp is a distinguished medical professional with over two decades of experience in diagnostic imaging and oncology. As the Oncology Chief Medical Officer at GE HealthCare, he has helped shaped the company's cancer care strategy, fostering partnerships with health systems worldwide. Ilya’s academic journey began with a Doctor of Medicine with a PhD in diagnostic radiology and diagnostic imaging. Prior to his tenure at GE HealthCare, Dr. Gipp held multiple roles at Royal Philips, culminating as Chief Medical Officer for Imaging and Oncology until 2023. Throughout his career, he has collaborated with leading health systems and governmental bodies globally to advance medicine and improve access to quality care. Connect with Ilya:LinkedIn: https://www.linkedin.com/in/ilyagipp/ Website: https://www.gehealthcare.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Michael Lahn, CMO at iOnctura – Osimertinib Success, TGF-Beta Lessons, Building Curious Teams, and More (00:31:33)
In this conversation, I talked with Michael Lahn, Chief Medical Officer of Ionctura, a clinical-stage biotech focusing on therapies for neglected and hard-to-treat cancers, where he shared his insights on drug development, leadership, and the importance of listening in building a successful team culture. He talked about his journey in the biotech industry, discussing the highs and lows of drug development, the lessons learned from his experiences with Osimertinib, and the common mistakes companies make. Michael emphasizes the significance of curiosity, collaboration, and a strong team dynamic in achieving success in the field of oncology.Here's what you're in:How did Michael get into drug development and what were some of the drivers that still push him today? What were some of the highest or proudest moments of his career? What are the key traits for success according to Michael?Timestamps:01:25 Michael's Journey into Drug Development03:28 Highest and Lowest Moments in Michael’s Career05:50 Lessons from Osimertinib Development07:50 Mistakes Companies Are Still Making Today10:26 The Importance of Listening in Leadership13:02 Ionctura's Mission and Achievements22:51 Recruitment and Working with Recruiters29:37 Final Reflections and GratitudeAbout MichaelMichael Lahn, the current Chief Medical Officer of iOnctura, a clinical-stage biotech focusing on therapies for neglected and hard-to-treat cancers. Michael completed training in Hematology-Oncology at the University of Freiburg in Germany and served as an Instructor in Immunology at the National Jewish Department of Immunology. He spent 14 years at Eli Lilly, became part of AstraZeneca's Osi-mertinib registration team, and later joined Incyte as the Head of the Geneva Office.Connect with MichaelLinkedIn: https://www.linkedin.com/in/michael-l-4a06519/ Company Website: https://www.ionctura.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Johan Baeck, EVP and CMO at Promontory Therapeutics – Cultural Fit in Hiring, Immunogenic Small Molecules, and Building Resilience in Biotech (00:32:01)
In this episode, I talked with Johan Baeck, Executive Vice President and Chief Medical Officer at Promontory Therapeutics, a clinical-stage biotech focused on developing novel small molecule immunogenic anti-cancer therapies.Johan shares insights from a career spanning large pharma (Novartis, Abbott) and biotech startups, with contributions to therapies like Vidaza, Kisqali, Zykadia, and PT-112. He also discusses why cultural fit is non-negotiable in hiring, how small molecules can trigger anti-tumor immune responses, and the personal journey of shifting from commercial to clinical focus.In this episode, we cover:How small molecules like PT-112 can trigger immune responses against cancer, and why this approach stands apart from traditional immunotherapies.Why cultural fit is a critical success factor for biotech hiring, and how the wrong hire can break a small company's momentum.How CMOs in biotech balance hands-on clinical work with C-suite leadership and constant fundraising challenges.Timestamps:01:26 Johan’s Journey: From practicing physician to entering pharma04:38 Lessons from a difficult career moment04:49 PT-112 and a novel approach to cancer treatment08:43 A culture of curiosity, openness, and diverse backgrounds10:15 Hiring the right fit: why technical skill isn’t enough18:46 Challenges facing CMOs in biotech23:46 What defines a high-performing clinical team26:03 Best and worst practices in recruitmentAbout JohanJohan Baeck is EVP and Chief Medical Officer at Promontory Therapeutics. His experience spans clinical development, medical affairs, and commercial operations across large pharma and biotech. He has contributed to the development of therapies like Vidaza, Kisqali, Zykadia, and PT-112, and has lived and worked across three continents, bringing a global perspective to clinical innovation.Connect with Johan:LinkedIn: https://www.linkedin.com/in/johanbaeck/Website: https://promontorytx.com/About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Peter Tummino, President of R&D at Nimbus Therapeutics – Drugging the Undruggable, The TYK2 Success Story, and Overhyping AI in Drug Discovery (00:27:12)
In this episode, I talked with Peter Tummino, President of Research and Development at Nimbus Therapeutics, where he discussed what it takes to build a successful biotech R&D engine. Peter shares his insights on company culture and its impact on drug discovery, the challenges of targeting difficult-to-drug proteins, and the lessons he’s learned from decades in pharma and biotech. He also reflects on leadership in R&D, the evolution of drug discovery strategies, and what excites him most about the future of the industry.Here's what you are in for:How does company culture influence scientific innovation in biotech?What are the biggest challenges in drug discovery, and how can teams overcome them?What lessons has Peter learned from his time at GSK, AstraZeneca, and Nimbus?What does the future of small molecule drug development look like?Timestamps:01:09 Career Journey05:15 Challenges and Lessons Learned08:33 Overview of Nimbus Therapeutics10:14 Exciting Clinical Trials at Nimbus11:39 Culture at Nimbus Therapeutics15:25 Industry Observations and AI19:16 Recruitment Insights and Experiences25:06 Quick Fire QuestionsAbout PeterDr. Peter Tummino is the President of Research and Development at Nimbus Therapeutics, a clinical-stage biotech that designs and develops novel small molecule medicines targeting difficult-to-drug proteins. He has been in small molecule drug discovery for over thirty years, including the past 6 with Nimbus.While at GSK, he contributed to the discovery of the approved oncology drugs (Dabrafenib, Trametinib, and Daprodustat for chronic kidney disease). At Nimbus, he led discovery during the development of Zaso-ci-tinib, which is currently in Phase 2 & 3 for psoriasis and other I&I clinical indications.Connect with PeterLinkedIn: https://www.linkedin.com/in/peter-tummino-7496753/ Nimbus Therapeutics: https://www.nimbustx.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Abigail Jenkins, CEO and Board Member – From Government Scientist to CEO, Launching a Stem Cell Therapy During Crisis, and Lessons in Commercial Strategy (00:32:16)
In this episode, I talked with Abigail (Abbey) Jenkins, a pharmaceutical executive with 25+ years of experience, who shares her career journey, highlighting her entry into the industry, proud achievements, and the challenges she faced along the way. She emphasizes the importance of resilience, community, and learning from both successes and failures. Abbey also discusses common mistakes companies make in the pharmaceutical industry, particularly regarding commercial potential and leadership culture. Our conversation concludes with insights on the significance of networking and support systems for women in leadership roles.Here's what you're in:How did she secure her first job in the industry? What were some of the highest and lowest moments of her career? About Biotech CEO Sisterhood.Timestamps:01:04 Early Career and Entry into Pharmaceuticals02:42 Proud Moments and Achievements in the Industry06:07 Challenges and Learnings from Difficult Time14:23 Industry Insights: Common Mistakes Companies Make19:43 Leadership Challenges: People and Culture Mistakes23:49 Quickfire Round: Personal Insights and Preferences26:31The Importance of Community: CEO SisterhoodAbout AbigailAbigail Jenkins is a pharmaceutical executive with 25+ years of experience, most recently as CEO of Gamida Cell, where she led the FDA approval and launch of the first "pharmaceutical-grade" stem cell transplant. Previously, she was Chief Commercial and Business Officer at Lyndra Therapeutics, developing an ultra long-acting oral drug delivery platform, and SVP, Vaccines Business Unit Head at Emergent BioSolutions, leading a global team of 600 employees. She currently serves on the boards of A-questive Therapeutics and (ZOR-TEX) XORTX Therapeutics.She began her career on the commercial side of the business, working in roles across all domains of sales, marketing, market access, operations, before expanding into business development, corporate strategy, and general management roles.Connect with AbigailLinkedIn: https://www.linkedin.com/in/abigail-jenkins-a713147/ About Biotech CEO SisterhoodThe Biotech CEO Sisterhood is a vibrant community dedicated to championing the success of women leaders in the biopharma industry. Rooted in a culture of mutual support and authenticity, the Sisterhood aims to inspire and uplift women while driving meaningful conversations and impact across the industry. As part of our commitment to nurturing the current and future generations of biotech leaders, the Sisterhood hosts summits, local events, and educational sessions. These programs encourage dialogue about the challenges facing women in biotech, share best practices, and enhance leadership effectiveness.LinkedIn: https://www.linkedin.com/company/biotech-ceo-sisterhood/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and...
Joseph Birkett, Executive Director at Aura Biosciences – Obinutuzumab's Approval, CDK9 Trial Regret, CRO Reliance, and Building Respectful Cultures (00:33:00)
Joseph (Joe) Birkett, Executive Director of Medical Affairs at Aura Biosciences, joined our podcast to share what he’s learned over two decades in oncology drug development, including the career-defining moments and the painful missteps that shaped his approach.Joe speaks openly about his proudest contribution—helping lead Obinutuzumab to regulatory approval—and contrasts it with one of his lowest points: watching leadership ignore safety concerns around a CDK9 inhibitor that ultimately failed in the clinic.Here's what you're in:How Joe helped lead Obinutuzumab to Phase III and approval.The fallout of pushing a CDK9 inhibitor with flawed preclinical data.His experience as a CEO and the lessons he carries forward.Timestamps:02:22 Working on Obinutuzumab and its approval04:51 Dealing with toxic leadership and moving on07:18 Introducing Aura Biosciences 15:01 What Joe looks for when hiring at Aura19:32 Why companies rely too much on CROs24:44 The problem with safe bets and risk-averse R&D29:47 Quickfire round About JoeJoseph Birkett is the Executive Director of Medical Affairs at Aura Biosciences, a clinical-stage biotech company developing virus-like drug conjugates (VDCs) to treat cancers such as uveal melanoma. Joe has 25 years of oncology drug development experience, contributing to the approval of seven oncology drugs across multiple disease areas.Prior to joining Aura Biosciences, he served as CEO of a stealth-mode EU biotech and is the founder of Crest Pharma. He holds a PhD in Psychiatric Medicine from King’s College London, and his passion extends beyond drug development to longevity, health, and wellness.Connect with JoeLinkedIn: https://www.linkedin.com/in/joseph-birkett-14572410/ Company Website: https://www.aurabiosciences.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/ Website: https://www.discera-search.com/ Opinions and comments expressed by the guest do not represent the company and are fully their own.
Bruce Dezube, Senior Vice President, Clinical Development at Xilio Therapeutics – HIV & Cancer Drug Development, Career at 60, Building Respectful Teams, and More (00:32:51)
In this episode, I talked with Dr. Bruce Dezube, Senior Vice President, Clinical Development of Xilio Therapeutics, a clinical-stage biotechnology company focused on developing tumor-activated immuno-oncology therapies. Here he shares his extensive career in oncology and drug development, discussing his journey from academia to industry, the challenges he faced, and the importance of patient care. He reflects on his experiences with HIV patients, the role of executive coaching in his career transition, and the vibrant culture at Xilio Therapeutics. Bruce emphasizes the significance of staying committed to a company for growth and contribution, and he offers valuable insights on leadership and teamwork.Here's what you're in:What is the specific moment in his life or career that helped drive him to where he is today?The benefits of having an executive coach.What did he learn from his career transition during his 60s?Timestamps:01:30 Career Beginnings in Medicine and Oncology04:45 Transition to HIV Treatment and Impactful Moments10:17 The Benefits of Having an Executive Coach 16:24 Career Transition at 60s20:05 About Xilio Therapeutics and its Culture28:12 Final AdviceAbout BruceBruce Dezube is the current Senior Vice President, Clinical Development of Xilio Therapeutics, a clinical-stage biotechnology company focused on developing tumor-activated immuno-oncology therapies. He has worked in drug development, both in oncology and in HIV, for most of his 40 year career. He is proud to have led and contributed to teams that brought life-changing medicines to patients. He considers these patients on early treatment to be pioneers. Although he has not explored seas like Columbus or Magellan, he views his efforts as those of a modern-day explorer.Connect with Bruce:LinkedIn: https://www.linkedin.com/in/bruce-dezube/ Company Website: https://xiliotx.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Chris Lowe, CEO at Nusano - Radioisotopes, Volunteering in Hospitals, Culture Building, and More (00:31:38)
In this episode, I talked with Chris Lowe, CEO of Nusano, where he discusses his career journey in the medical technology field, particularly focusing on the production of medical radioisotopes. He shares insights on leadership, the importance of building a talented team, and the societal responsibilities of his company. Chris also highlights common mistakes in drug development and reflects on a case study from his past. Our conversation emphasizes the significance of patient-centric approaches in the industry.Here's what you're in:The highest and lowest career points of Chris’ career. Why medical radioisotopes production is so important and how Nusano is approaching this. Exploring mistakes that companies are still making today. Timestamps:04:51 Proudest Moment of Chris in his Career and Leadership Philosophy07:41 Nusano: Innovations in Medical Radioisotope Production13:55 Building a Talented Team at Nusano17:57 Company Culture and Societal Responsibility19:48 Common Mistakes Companies Are Still Making Today22:40 Case Study: The Francis Trial30:24 Final Thoughts on Patient-Centric Drug DevelopmentAbout ChrisChris Lowe is the CEO of Nusano, a privately-held medical technology company that specializes in the production of medical radioisotopes used for diagnosing and treating diseases such as cancer. Chris has led 5 IPOs as a C-level executive, all focused on supporting therapeutic development, while efficiently building and scaling operations.Prior to this, he spent 3 years with Cortexyme as COO and CFO. He has over 15 years of C-Suite experience in various private and public life sciences, medical technology, and technology companies.Connect with ChrisLinkedIn: https://www.linkedin.com/in/chrislowe7/ Company Website: https://nusano.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Kevin Lynch, co-Founder PopulusBio - Career at Celgene, How Culture Influences Drug Development and more (00:40:28)
In this podcast episode, I talked with Kevin Lynch, co-founder of Populus Bio, where he shares his experience in drug development, particularly in oncology and hematology. He discusses his journey from medicine to the pharmaceutical industry, the cultural insights gained from working globally, and the challenges faced in both personal and professional aspects. Kevin elaborates on the innovative management approach at Populus Bio, the common mistakes made in clinical trials, and the importance of understanding biology in drug development. He also provides valuable lessons on hiring and leading teams, as well as insights into improving the recruitment process in the biotech industry.Here's what you're in:How cultural differences significantly impact on global operations of companies?How important is understanding the science behind drug development?What are big mistakes companies are still making today?Timestamps:01:38 Kevin's Early Career and Medical Journey05:05 Transition to the Pharmaceutical Industry10:37 Building and Leading Biotech Companies12:16 Challenges and Learnings in Drug Development15:32 Populus Bio's Unique Approach22:01 Industry Observations and Mistakes31:44 Hiring and Leading People in Biotech36:07 Career Advice and MentorshipAbout KevinDr. Kevin Lynch is the co-Founder, Populus Bio, a company focused on accelerating the development of therapies for debilitating diseases. He is a physician with more than 30 years experience in drug development, mainly oncology and haematology. He has worked across multiple geographies in senior roles for large, multi-nationals as well as smaller, start up companies. Previous to this he worked at Immodulon Therapeutics and as the CMO for Antengene for almost 2 years. When I asked Kevin about a proud career moment it was “Development of imatinib and facilitating one country's (Australia) role in helping define a standard of care.” He is here today on the podcast to share his career and insights from the industry. Connect with KevinLinkedIn: https://www.linkedin.com/in/kevin-lynch-6910742b/ Company Website: https://populusbio.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Victor Paulus, SVP Regulatory Affairs at ARTBIO - Lutathera Approval and Lessons, Falling from Trees, ARTBIO's Culture (00:35:50)
In this episode, I talked with Victor Paulus, Senior Vice President and Head of Regulatory Affairs at ARTBIO, where he shares his journey in the life sciences industry, discussing his career journey, challenges faced in regulatory affairs, and the unique culture at ARTBIO. He emphasizes the importance of collaboration, mentorship, and understanding the regulatory landscape to achieve success in drug development. Victor also provides valuable insights into industry observations and offers career advice for those starting in the field.Here's what you're in:What made Victor get into life science and what attracted him to regulatory affairs?The challenges faced and approval of Lutathera.Why regulatory professionals should be involved early in the development process?Timestamps:01:40 Victor's Early Career Journey06:04 Career Highlights: The Approval of Lutathera10:25 Challenges in Regulatory Affairs: The CMC Vaccine Program18:58 The Culture and Vision at ARTBIO25:07 Industry Observations and Common Mistakes30:56 Career Advice for New ProfessionalsAbout VictorVictor Paulus is the Senior Vice President and Head of Regulatory Affairs of ARTBIO, a clinical-stage radiopharmaceutical biotechnology. Prior to ARTBIO, he served as Senior Vice President of Regulatory Affairs for two years at Fusion Pharmaceuticals and also worked at AAA during the Lutathera approval. He has also worked on approvals including FluZone, Ze-mere-ra ,Pedia-rix, Anthim, Annovera, and Lutathera. Outside of his professional life, he has been passionate about environmental pursuits and enjoys activities such as birding, hiking, and spending time in the woods.Connect with VictorLinkedIn: https://www.linkedin.com/in/victor-paulus-25994a3/ Company Website: https://artbio.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn:https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Chris Leamon, CSO at Fusion Therapeutics - Acquisition of Endocyte, Career reflections and more (00:37:25)
In this episode, I talked with Dr. Chris Leamon, Chief Scientific Officer at Fusion Pharmaceuticals, where he shares his journey in the biotech industry, discussing his early influences, the founding of Endocyte, and . He also discusses the challenges faced in drug development, the importance of leadership during workforce reductions, and the lessons learned from trial failures. Chris emphasizes the significance of execution, continuous learning, and building a strong team in the biotech field.Here's what you're in:What made Chris pursue a career in oncology?Why did Chris join Fusion Pharmaceuticals?What are big mistakes companies are still making today? Timestamps:02:41 Early Influences and Career Beginnings06:43 Transitioning into Radiotherapeutics Field13:36 The Process of Pivoting Trials16:50 Dealing with Workforce Reduction20:53 Joining Fusion Pharmaceuticals and Future Aspirations24:36 Insights on Trial Failures and Learning Experiences29:17 Hiring Practices and Building a Strong Team34:11 Advice for Aspiring Biotech Professionals About ChrisDr. Chris Leamon is the Chief Scientific Officer at Fusion Pharmaceuticals, a clinical-stage biopharmaceutical company that specializes in developing targeted alpha therapeutics for the treatment of cancer. He is also a scientific co-founder of Endocyte, the company that developed Pluvicto, and he has been an executive associated with two biotech acquisitions over the past six years: Endocyte (purchased by Novartis in Dec. 2018) and Fusion Pharmaceuticals (purchased by Astra Zeneca in June, 2024). Dr. Leamon earned his PhD in Biochemistry at Purdue University.Connect with ChrisLinkedIn: https://www.linkedin.com/in/chris-leamon-393639b/ Company Website: https://fusionpharma.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn:https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Dawn Rubel, Dawn Rubel, President R&D at NexEos Bio - Eosinophilic Esophagitis, Purposeful Leadership and more (00:34:39)
In this episode, I talked with Dawn Rubel, President of R&D at NexEos Bio, where she shares her career journey from a scientific technical writer to a leadership role in biotech. She discusses her experiences at Immunomedics, the development of Trodelvy, and her transition to NexEos Bio, where she focuses on eosinophilic inflammation. Dawn emphasizes the importance of teamwork, hiring the right people, and learning from failures in clinical trials. She also provides valuable advice for aspiring leaders and highlights the significance of passion in one's work.Here's what you're in:Why did Dawn move into quality, regulatory, and leadership instead of staying in technical writing?What is the biggest lesson she learned from her career journey?Who does Nexeos Bio aim to help, and what is the company’s approach?Timestamps01:52 Dawn's Career Journey05:20 Immunomedics and Troldevy08:05 Joining Nexeos Bio 11:47 Challenges and Opportunities at NexEos Bio15:09 Failures and Lessons in Clinical Trials22:10 Insights About Hiring and Leadership 31:25 Advice for Aspiring LeadersAbout DawnDawn Rubel is the President of Research and Development at NexEos Bio, a privately held medical diagnostics and therapeutics company focused on developing innovative technologies for eosinophil-mediated diseases. Dawn has successful leadership experience in Biotech, Pharma, Medical Device from global multibillion-dollar corporations (Pfizer, Arthrex) to small biotechs (Immunomedics, NexEos Bio). She held leadership roles in safety, quality, & regulatory in her previous companies. She earned an MBA in Fairleigh Dickinson University and she did her Graduate Studies in Industrial Pharmacy, Pharmaceutics and Drug Design in Long Island University.Connect with DawnLinkedIn: https://www.linkedin.com/in/dawn-rubel/ Company Website: https://www.nexeosbio.com/ About MeMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Örn Almarsson, Co-Founder of Axelyf - Modernas SpikeVax, the challenge of mRNA delivery and Salmon's inspiration behind Axelyf? (00:35:35)
In this episode, I talked with Orn Almarsson, co-founder of Axelyf, where he shared his journey from Iceland to becoming a prominent figure in the biotechnology industry. He discussed his experiences at Moderna and the development of the mRNA COVID vaccine, Spikevax. He reflects on the challenges faced in drug development, the importance of mentorship, and the founding of his own company, Axelyf, which focuses on anti-inflammatory solutions. Orn emphasizes the significance of hiring passionate individuals, the need for feedback in recruitment, and the value of networking and mentorship for career success.Here's what you're in:What success has he worked on Spikevax mRNA COVID vaccine, and what has he learned from it?What is Axelyf and its mission?What qualities of an individual is important when it comes to hiring?Timestamps:02:06 From Iceland to California05:55 Joining Merck and Early Experiences07:44 The Moderna Journey and Spikevax15:26 Founding Axelyf and Its Mission22:39 Industry Observations and Hiring Insights32:14 Advice for Aspiring ProfessionalsAbout OrnOrn Almarsson, co-founder of Axelyf, an Icelandic biotechnology start-up focusing on designing and developing medicines for inflammatory and autoimmune conditions. Orn is a pharmaceutical scientist turned executive with 30 years in the industry and has worked with multiple products including the Covid vaccine, Spikevax at Moderna. He has a PhD in Bioorganic Chemistry from UC Santa Barbara, originally from Iceland but now lives in Massachusetts.Connect with OrnLinkedIn: https://www.linkedin.com/in/%C3%B6rn-almarsson-9511b86/ Company Website: https://www.axelyf.com/ About meMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch my firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn:https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
Leila Jaafar, CEO at Nuclidium - from PhD to Radiotherapy CEO (00:31:52)
In this episode, I talked with Dr. Leila Jaffar, CEO of Nuclidium, where she shares her journey from a childhood influenced by her father's passion for science to becoming a leader in the biotech industry. She discusses the challenges she faced during her career, including personal and professional, and her transition from academia to industry. Leila elaborates on the mission of Nuclidium, focusing on the development of copper-based diagnostics and therapeutics for oncology. She also emphasizes the importance of company culture, the impact of every team member, and the lessons learned in leadership and hiring. Here's what you're in:What is the goal with Nuclidium? How can networking becomes crucial for career advancement?Why did you decide to go down the founder route? Timestamps:02:08 Journey into Life Sciences04:26 Dealing With Career's Lowest Point09:31 Getting A Job After Finishing PhD11:09 Founding of her Own Company14:37 Nuclidium and What Sets It Apart21:55 Why Join Nuclidium - What is its Culture?24:22 Lessons Learned Through Hiring and Managing People27:38 Quickfire QuestionsAbout LeilaDr. Leila Jaafar, CEO of Nuclidium, a clinical-stage radiopharmaceutical working on copper-based diagnostics and therapeutics. Dr. Leila is also the co-founder of LinaThera, which is partnered with Nuclidium and focuses on the production of medical radionuclides. Prior to joining Nuclidium, she was the CEO of Swiss Nuclides for 5 years and Program Manager at Areva for 6 years. Outside of her professional role, she plays the violin and loves to read in her free time.Connect with LeilaLinkedIn: https://www.linkedin.com/in/leila-jaafar-605642130/ Company Website: https://nuclidium.com/ About MeMy name is Charles Spence and I lead Discera. After many years working in the life-science recruitment world, I decided to work for myself. Before doing recruitment I graduated with a biomedical degree, have worked in hospitals (including translation work in Seoul, South Korea), and also spent a year working in diabetes research in Stockholm. After doing research and travel, a career in business and science felt the most appropriate.In 2023, I decided to launch his firm - Discera Search. A firm committed to solving the biggest talent needs of early clinical stage SME biotechs on the East Coast and DACH.Connect with me:LinkedIn: https://www.linkedin.com/in/charles-spence-clinical/Website: https://www.discera-search.com/Opinions and comments expressed by the guest do not represent the company and are fully their own.
