DiabetesBio co-hosts Darleen Sandoval (University of Colorado), Kirk Habegger (University of Alabama-Birmingham), and Kevin Williams (UT Southwestern) interview authors of editor-selected biomedical research articles published in the journal Diabetes, the American Diabetes Association's flagship research publication.
📻 Siste episoder av DiabetesBio
Her er de nyeste episodene tilgjengelige via RSS-feeden:
Bergman on altering lipid localization and adipose tissue cellular composition through weight loss and exercise, Walters, Castro-Gutierrez, Mukherjee & Russ on HLA immune presentation on Human β-Cells, metabolic "Sweet Talk" with Banks, Holman, & Lan (01:35:17)
Welcome to the December 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2025 issue of Diabetes. 13:10 After discussing their favorite interviews of the past two years, our hosts are joined by Bryan Bergman, PhD, a professor in the Division of Endocrinology, Metabolism, and Diabetes at the University of Colorado Anschutz Medical Campus. He is the corresponding author of "Combined Weight Loss and Exercise Training Alters Skeletal Muscle Subcellular Lipid Localization and Intermuscular Adipose Tissue Cellular Composition," a featured article in this month's issue. The article is available for free at doi.org/10.2337/db25-0492. 35:25 To discuss the latest Paper of the Month, our hosts are joined by authors Kathryn Walters, PhD, postdoctoral researcher at CU Anschutz, Roberto Castro-Gutierrez, PhD, a postdoctoral fellow at the University of California San Francisco, Neelanjan Mukherjee, PhD, Assistant Professor in the Department of Biochemistry and Molecular Genetics at the CU Anschutz, and Holger Russ, PhD, Associate Professor in the Department of Pharmacology and Therapeutics at the University of Florida. Their article, "Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human β-Cells," is available for free at doi.org/10.2337/db24-0527. 1:00:50 In the latest edition of "Sweet Talk," Kevin and Kirk explore how new technologies shape the ways we assess metabolism. They are joined by Alexander Banks, PhD, Director of the Energy Balance core facility at Beth Israel Deaconess Medical Center (BIDMC) at Harvard Medical School, Corey Holman, PhD, Technical Director of the Rodent Metabolic Phenotyping Core at the University of Pennsylvania, and Louise Lantier, PhD, Metabolic Pathophysiology Core Managing Director at Vanderbilt University Medical Center. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Kaylia Reynolds and Nora Franceschini on diabetes genetic clusters, Stephanie Holm & Christoffer Clemmensen on sustained weight loss with LEAP2 & Semaglutide, plus "Sweet Talk" with Banting Medal recipient Jens Juul Holst (01:06:37)
Welcome to the November 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2025 issue of Diabetes. 6:00 In the first segment, our hosts are joined by Kaylia Reynolds, MS and Nora Franceschini, MD, MPH, FAHA, both of the Department of Epidemiology at the Gillings School of Global Public Health at the University of North Carolina. Their paper, "Diabetes Genetic Clusters and Clinical Outcomes in American Indians," is available for free at doi.org/10.2337/db25-0322. 20:40 To discuss the latest Paper of the Month, our hosts are joined by first author Stephanie K. Holm, a postdoctoral student in the Clemmensen group, and Christoffer Clemmensen, Associate Professor in the Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen. Their paper, "Sustained Weight Loss With Combined LEAP2 and Semaglutide Treatment in Mice," is available for free at doi.org/10.2337/db24-1056. 38:15 In the latest edition of "Sweet Talk," Kevin and Kirk speak with Banting Medal recipient Jens Juul Holst, MD, DMSc, of the University of Copenhagen, whose work with incretin hormones laid the foundation for therapies now used around the world. His article, "Treatment of Type 2 Diabetes and Obesity on the Basis of the Incretin System: The 2021 Banting Medal for Scientific Achievement Award Lecture," is available for free at doi.org/10.2337/dbi21-0026. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Cacciottoloon on glucagon receptor deficiency & early-onset hepatic steatosis, "Sweet Talk" on childhood obesity with Nadeau & Cartwright, plus a special segment: speaking to kids directly with their questions about diabetes and obesity (01:07:35)
Welcome to the October 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2025 issue of Diabetes. 5:50 In the first segment, our hosts are joined by Tessa M. Cacciottolo, PhD, a Chain Florey TTI Fellow in the MRC Laboratory of Medical Sciences at Imperial College London. She is the first author of the article "Glucagon Receptor Deficiency Causes Early-Onset Hepatic Steatosis," available for free at doi.org/10.2337/db25-0209. 22:15 In honor of last month being Childhood Obesity Month, in this month's edition of "Sweet Talk", our hosts speak with Kristen Nadeau, MD, MS, a professor of pediatrics at the University of Colorado Anschutz Medical Campus, and Bethany Cartwright, MD, PhD, an Assistant Instructor in the Department of Pediatrics at UT Southwestern Medical Center. They discuss the complications children with obesity can face, as well as the stigma and weight biases that accompany these diagnoses. Cartwright's article, "Adipose Tissue as a Target for Precision Medicine Approaches in Childhood Obesity," is available for free at doi.org/10.2337/dbi24-0044. 49:10 In a special segment, Nadeau and Cartwright take questions directly from kids of various ages on the topics of diabetes and obesity. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Quarta on GLP-1-mediated targeting of inflammation and obesogenic memory in mice, Hsueh on dulaglutide and hepatic steatosis in obesity via a weight-independent mechanism, & "Sweet Talk" with Pathway to Stop Diabetes Award recipient Alexander Nectow (01:06:40)
Welcome to the September 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2025 issue of Diabetes. 5:25 In the first segment, our hosts are joined by Carmelo Quarta, PhD, a principal investigator at INSERM (National Institute of Health and Medical Research) and a group leader at the Bordeaux Neurocampus at the University of Bordeaux in France. He is the co-corresponding author of "GLP-1–Mediated Targeting of Inflammation Corrects Obesogenic Memory in Male Mice," available for free at doi.org/10.2337/db24-1071. 27:30 Next, Darleen and Kirk speak with Willa A. Hsueh, MD, Professor of Medicine in the Division of Endocrinology at the Ohio State University College of Medicine. She is a corresponding author on this month's Paper of the Month, "The GLP-1 Receptor Agonist Dulaglutide Attenuates Hepatic Steatosis in Obesity via a Weight-Independent Mechanism," available for free at doi.org/10.2337/db24-0861. 46:20 Lastly, in this month's edition of "Sweet Talk," Kevin and Darleen are joined by Alexander R. Nectow, MD, PhD. A recipient of the American Diabetes Association's Pathway to Stop Diabetes Award, Dr. Nectow lab at Columbia University studies the dorsal raphe nucleus (DRN) and its relation to metabolism. His article, "The Dorsal Raphe Nucleus and the Integrative Control of Feeding: A Report on Research Supported by Pathway to Stop Diabetes," is available for free at doi.org/10.2337/dbi24-0015. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Special Edition: Highlights from the ADA's 2025 Scientific Sessions (00:38:42)
In this special crossover episode, recorded live at the American Diabetes Association's 85th Scientific Sessions in Chicago, the hosts of ADA's professional podcasts—Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio—come together to discuss key highlights and groundbreaking research presented at the 2025 meeting. They share expert insights across the bench-to-bedside spectrum, including basic science, clinical research, and the latest in diabetes care and education. Tune in for thoughtful reflections on what this year's findings mean for clinical practice and future research. Available now across all ADA professional podcast channels. Featured Podcasts: DiabetesBio – From ADA's flagship research journal, Diabetes Diabetes Care "On Air" – From ADA's clinical research journal, Diabetes Care Diabetes Core Update – ADA's podcast for primary care Join the Discussion with: Alice Cheng, MD – Co-host of Diabetes Care "On Air" Kirk Habegger, PhD – Co-host of DiabetesBio Michael Rickels, MD, MS – Co-host of Diabetes Care "On Air" Darleen Sandoval, PhD – Co-host of DiabetesBio Neil Skolnik, MD – Co-host of Diabetes Core Update and Diabetes Day by Day Kevin Williams, PhD – Co-host of DiabetesBio 🔗 Learn more about ADA's full podcast portfolio: https://diabetesjournals.org/journals/pages/podcasts Subscribe to Diabetes Core Update, Diabetes Care "On Air", and DiabetesBio on Apple Podcasts, Amazon Music, Spotify, or your preferred platform.
A special extended "Sweet Talk" episode on the debate between GIP receptor agonism and GIP receptor antagonism, with Daniel Drucker, OC, MD, FRCPC, FRSC, FRS, and Jonathan Campbell, PhD. (00:59:51)
Welcome to the August 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2025 issue of Diabetes. 6:55 For this month's episode, a special extended edition of "Sweet Talk," exploring the debate about whether GIP receptor agonism or GIP receptor antagonism holds the most promise for therapeutic strategies. First, our hosts are joined by Daniel J. Drucker, OC, MD, FRCPC, FRSC, FRS, recipient of the American Diabetes Association's (ADA) 2014 Banting Medal for Scienfitic Achievement for his research with GLP-1s. They also speak with Jonathan Campbell, PhD, Associate Professor in Medicine at the Duke Molecular Physiology Institute at Duke University. They discuss the history of endocrine biology research and their article, "Therapeutic Targeting of the GIP Receptor—Revisiting the Controversies," available for free at doi.org/10.2337/db25-0393. 42:00 As the conversation continues, our guests discuss the controversy of the GIP receptor agonism, antagonism debate. These arguments are highlighted in a special debate series in the August issue of Diabetes, featuring a point article, "A Contemporary Rationale for Agonism of the GIP Receptor in the Treatment of Obesity," available for free at doi.org/10.2337/dbi24-0026, and a counterpoint article titled "GIP Receptor Antagonists in the Pharmacotherapy of Obesity: Physiologic, Genetic, and Clinical Rationale," also available for free at doi.org/10.2337/dbi24-0027. And don't forget to reach out! Let us know your stance in the debate between agonism and antagonism, and share your favorite science-related podcasts! To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Suganami & Tanaka on regulation of adipose tissue fibrosis, Watanabe on genetic variations in GCKR & PNPLA3 regulating metabolic balance across the liver, "Sweet Talk" with the 2025 Albert Renold Distinguished Career Award recipient Barbara B. Khan (01:18:40)
Welcome to the July 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2025 issue of Diabetes. 6:50 In the first interview segment, our hosts discuss July's Paper of the Month, titled "Novel Cell-to-Cell Communications Between Macrophages and Fibroblasts Regulate Obesity-Induced Adipose Tissue Fibrosis." They're joined by corresponding authors Dr. Takayoshi Suganami, professor in the Department of Molecular Medicine and Metabolism, the Research Institute of Environmental Medicine at Nagoya University in Nagoya, Japan, and Miyako Tanaka, a lecturer in the same department. This article is available for free at doi.org/10.2337/db24-0762. 22:25 Our hosts speak with Richard M. Watanabe, PhD, Professor of Population and Public Health Sciences in the Department of Population and Public Health Sciences at the University of Southern California Keck School of Medicine. His paper, "Genetic Variations in GCKR and PNPLA3 Regulate Metabolic Balance Across the Liver," is available at doi.org/10.2337/db24-0923. 46:50 In this month's edition of "Sweet Talk," our hosts are joined by Barbara B. Kahn, MD, recipient of the American Diabetes Association's Albert Renold Distinguished Career Award, to discuss her work uncovering key molecular mechanisms contributing to type two diabetes and the role of adipose tissue in regulating systemic insulin sensitivity. Dr. Kahn is the George Richards Minot Professor of Medicine at Harvard Medical School and Vice Chair for Research Strategy at Beth Israel Deaconess Medical Center in Boston. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Okamoto & Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Kowalski on the effect of small blood glucose increases on endogenous glucose production, Sweet Talk with the 2025 Outstanding Scientific Achievement Award recipient Kajimura (00:55:11)
Haruka Okamoto & Kehan Bao on hepatic PKA mediating liver and pancreatic α-cell cross talk, Greg Kowalski on the effect of small blood glucose increases on endogenous glucose production, and "Sweet Talk" with the 2025 Outstanding Scientific Achievement Award recipient Shingo Kajimura. Welcome to the June 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2025 issue of Diabetes. 4:40 In the first interview segment, our hosts discuss June's Paper of the Month, titled "Hepatic PKA Mediates Liver and Pancreatic α-Cell Cross Talk." They're joined by corresponding author Dr. Haruka Okamoto, Director of Obesity Research at Regeneron Pharmaceuticals, and lead author Dr. Kehan Bao, a postdoctoral fellow at Regeneron. This article is available for free at doi.org/10.2337/db24-0958. 17:25 Our hosts speak with Greg M. Kowalski, PhD, Associate Professor with both the School of Medicine and the Institute for Physical Activity and Nutrition at the Deakin University's Faculty of Health in Victoria, Australia. He is the corresponding author of a featured article in the June issue, "The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans," available for free at doi.org/10.2337/db24-0388. 33:55 In this month's edition of "Sweet Talk," our hosts are joined by Shingo Kajimura, PhD, professor at Beth Israel Deaconess Medical Center in Boston and the recipient of the ADA's 2025 Outstanding Scientific Achievement Award. They discuss his work with brown and beige fat control and their effects on energy balance and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Michael Rickels on predicting metabolic outcomes through beta cell secretory capacity, Mark Atkinson on the ADA's upcoming Scientific Sessions, and 2025 Banting Medal recipient Steven Kahn (01:15:54)
Welcome to the May 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2025 issue of Diabetes. 6:25 In the first interview segment, our hosts discuss May's Paper of the Month, titled "β-Cell Secretory Capacity Predicts Metabolic Outcomes Over 6 Years After Human Islet Transplantation." They're joined by corresponding author Michael R. Rickels, MD, MS, Willard Rhoda Ware Professor in Diabetes and Metabolic Diseases in the Division of Endocrinology, Diabetes, and Metabolism Department of Medicine at the University of Pennsylvania Perelman School of Medicine, and and co-host of the podcast Diabetes Care On Air. This article is available for free at doi.org/10.2337/db24-0729 25:30 It's a special two-part edition of "Sweet Talk." In part one, our hosts focus on the upcoming 85th Scientific Sessions of the American Diabetes Association. They're joined by Mark A. Atkinson, American Diabetes Association Eminent Scholar for Diabetes Research and the Jeffrey Keene Family Professor at The University of Florida, and chair of this year's Scientific Sessions programming committee. 48:10 In part two, our hosts speak with Steven Kahn, MB, ChB, Professor of Medicine at the University of Washington (UW) and Director of the UW Diabetes Research Center. Dr. Kahn is the 2025 recipient of the American Diabetes Association's Banting Medal for Scientific Achievement, and he discusses his landmark paper, "Quantification of the Relationship Between Insulin Sensitivity and β-Cell Function in Human Subjects: Evidence for a Hyperbolic Function," available for free at doi.org/10.2337/diab.42.11.1663. They also discuss the legacy of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in honor of its 75th anniversary. A special compendium of NIDDK studies is available at diabetesjournals.org/collection/2745/NIDDK-75th-Anniversary-Collection. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Jennifer Bruin & Lahari Basu on cisplatin exposure and the dysregulation of insulin, Amit Majithia on AF-1 domain inhibition as an insulin sensitization target, and a Sweet Talk special remembrance with Maren Laughlin, Julio Ayala, and Shawn Burgess (01:12:02)
Welcome to the April 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2025 issue of Diabetes. 6:30 In the first interview segment, our hosts discuss an article titled "Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice." They're joined by corresponding author Jennifer E. Bruin, BSc, PhD, an associate professor in the Department of Biology and Institute of Biochemistry at Carleton University in Ottawa, Canada, and lead author Lahari Basu, PhD candidate at Carleton University. This article is available for free at doi.org/10.2337/db24-0419. 25:20 Our hosts discuss the latest Paper of the Month, entitled "An Alternatively Translated Isoform of PPARG Suggests AF-1 Domain Inhibition as an Insulin Sensitization Target." They're joined by corresponding author Amit R. Majithia, MD, Associate Professor in the Division of Endocrinology in the Department of Medicine at the UC San Diego School of Medicine. This article is available for free at doi.org/10.2337/db24-0497. 38:55 In the special edition of "Sweet Talk," our hosts reflect on the life and legacy of David Wasserman, PhD, a pioneer in metabolic research with a lasting impact in exercise physiology, glucose metabolism, and diabetes. They're joined by the people who knew him best: Maren Laughlin, PhD, Senior Advisor for Integrative Physiology at the National Institutes of Health, Julio Ayala, PhD, Director of the Vanderbilt Mouse Metabolic Phenotyping Center, and Shawn Burgess, PhD, professor at UT Southwestern Medical Center in Dallas, Texas. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Anne Gresch & Martina Düfer on resolving spatiotemporal electrical signaling within the islet, Delnaz Roshandel on the genetics of C-peptide and age, and a Sweet Talk history lesson with Jeffrey Flier & Christopher Newgard (01:06:37)
Welcome to the March 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2025 issue of Diabetes. 3:20 In the first interview segment, our hosts discuss the Paper of the Month, "Resolving Spatiotemporal Electrical Signaling Within the Islet via CMOS Microelectrode Arrays." They're joined by Anne Gresch, PhD, a postdoctoral fellow at the University of Colorado's Anschutz Medical Campus, and Prof. Dr. Martina Düfer, from the Department of Pharmacology at the University of Munster Pharmaceutical and Medicinal Chemistry in Munster, Germany. This article is available for free at doi.org/10.2337/db23-0870. 22:40 Our hosts discuss an article from the February issue of Diabetes, entitled "Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes." They're joined by lead author Delnaz Roshandel, PhD, Senior Research Associate, and Andrew Paterson, MD, both of the Genetics and Genome Biology Program at the Hospital for Sick Children in Toronto, Canada. This article is available for free at doi.org/10.2337/db24-0340. 36:20 In the special edition of "Sweet Talk," our hosts welcome Jeffrey S Flier, MD, former Dean of Harvard Medical School and past recipient of the ADA's Banting Medal, as well as Christopher Bang Newgard, PhD, leader in pancreatic islet biology and metabolic disease at Duke University School of Medicine and previous recipient of the ADA's Outstanding Scientific Achievement Award. They discuss an article by Diabetes editor-in-chief, David A. D'Alessio, on the historic development of the insulin radioimmunoassay, available for free at doi.org/10.2337/dbi24-0055. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Francis C. Lynn on tracking insulin- and glucagon-expressing cells, David C. Wraith & Michael J. Price on antigen-specific immunotherapy for T1D, and Sweet Talk with Bret H. Goodpaster (00:50:06)
Welcome to the February 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the February 2025 issue of Diabetes. 3:55 In the first interview segment, our hosts our joined by Francis C. Lynn, BSc PhD, Associate Professor in the Department of Surgery and School of Biomedical Engineering at the University of British Columbia in Vancouver. He is the corresponding author of the article "Tracking Insulin- and Glucagon-Expressing Cells In Vitro and In Vivo Using a Double-Reporter Human Embryonic Stem Cell Line." The article is available for free at doi.org/10.2337/db24-0756. 18:25 Darleen, Kevin, and Kirk speak with David C. Wraith, PhD, Emeritus Professor of Immunology, and Michael J. Price, PhD, a research fellow, both at the Institute of Immunology and Immunotherapy at the University of Birmingham in the UK. They discuss their article, "Pre-clinical development of a tolerogenic peptide from glutamate decarboxylase as a candidate for antigen-specific immunotherapy in type 1 diabetes," available at doi.org/10.2337/db23-0996. 35:50 In the latest edition of "Sweet Talk," our hosts welcome Bret H. Goodpaster, PhD, Scientific Director and Senior Investigator at the AdventHealth Translational Research Institute for Metabolism and Diabetes in Orlando, FL, and Professor of Medicine at Johns Hopkins University. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Philipp Scherer & Joel Elmquist on the interplay between the brain and adipose tissue and Jonathan Flak on the brain's role in glucose regulation, energy balance, and bodyweight control. (00:49:44)
Welcome to the January 2025 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the January 2025 issue of Diabetes. 2:00 In a special format for the first episode of the new year, our hosts introduce a Sweet Talk double feature. 3:35 In part one of this special Sweet Talk segment, our hosts are joined by Philipp Scherer, PhD, Professor in the Department of Internal Medicine at the University of Texas Southwestern Medical Center in Dallas, Texas, and Director of the Touchstone Diabetes Center, and Joel Elmquist, DVM, PhD, Professor of Internal Medicine at UT Southwestern Medical Center, and Director of its Center for Hypothalamic Research. Both are previous recipients of the ADA's Outstanding Scientific Achievement Award, and Scherer recently received the ADA's Banting Medal. They share their perspectives on the evolution of diabetes, obesity research, the interplay between the brain and adipose tissue, and what the future holds for understanding and treating these complex diseases. 33:00 In part two, our hosts speak with Jonathan Flak, PhD, Assistant Professor of Pharmacology & Toxicology at the Indiana University School of Medicine, and former recipient of the ADA's Pathway to Stop Diabetes Award. He discusses his work on the brain's role in glucose regulation, energy balance, and bodyweight control. His article, "Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes: A Report on Research Supported by Pathway to Stop Diabetes," can be found in the January 2025 issue of Diabetes. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Stilgenbauer & Sadagurski on the link between airborne pollutants and metabolic disease, Petersen on the effect of weight loss on skeletal muscle bioactive lipids, and Page & Alves on the neurodevelopmental pathways to obesity and type 2 diabetes. (01:05:23)
Welcome to the December 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the December 2024 issue of Diabetes. 0:55 In celebrating the one-year anniversary of DiabetesBio, our hosts highlight a few of their favorite articles from the last year. These include: Ueki et al. Establishment of Pancreatic β-Cell–Specific Gene Knockout System Based on CRISPR-Cas9 Technology With AAV8-Mediated gRNA Delivery doi.org/10.2337/db23-0445 Bruce et al. The Effect of Small Increases in Blood Glucose on Insulin Secretion and Endogenous Glucose Production in Humans doi.org/10.2337/db24-0388 Furber et al. GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice doi.org/10.2337/db23-0172 Greenbaum et al. Evolving Concepts in Pathophysiology, Screening, and Prevention of Type 1 Diabetes: Report of Diabetes Mellitus Interagency Coordinating Committee Workshop doi.org/10.2337/dbi24-0020 Ramos et al. Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults With Diabetes doi.org/10.2337/db23-0827 Bonifazi et al. Development of Novel Tools for Dissection of Central Versus Peripheral Dopamine D2-Like Receptor Signaling in Dysglycemia doi.org/10.2337/db24-0175 6:15 Darleen is joined by Lukas Stilgenbauer of the Department of Biological Sciences at Wayne State University in Detroit, Michigan, as well as Mariana Sadagurski, associate professor in the Institute of Environmental Health Sciences and Integrative Biosciences Center at Wayne State University. They discuss their article "Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling." This article is available for free at doi.org/10.2337/db24-0110 33:45 Kirk and Kevin dive into the December issue's Paper of the Month, "Effect of Weight Loss on Skeletal Muscle Bioactive Lipids in People With Obesity and Type 2 Diabetes." They're joined by lead author Max Petersen, an instructor at the Division of Endocrinology, Metabolism, & Lipid Research at Washington University School of Medicine in St. Louis, Missouri. The article is available for free at doi.org/10.2337/db24-0083. 47:20 Finally, this month's edition of Sweet Talk focuses on work funded by the American Diabetes Association's Pathway to Stop Diabetes initiative. Kathleen Alanna Page, Associate Professor of Medicine at the University of Southern California's Keck School of Medicine, and Jasmin Alves, a postdoctoral research fellow with Page, stop by to discuss Page's study, "Neurodevelopmental Pathways to Obesity and Type 2 Diabetes: Insights From Prenatal Exposure to Maternal Obesity and Gestational Diabetes Mellitus: A Report on Research Supported by Pathway to Stop Diabetes." The article is available at doi.org/10.2337/dbi24-0012 To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Maxwell and Grillo on the link between feeding behaviors and leptin activation of dorsal raphe neurons, Fruttiger on microvascular damage and neurodegeneration in early diabetic retinopathy, and Yeo on the genetics of metabolic health. (01:14:18)
Welcome to the November 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the November 2024 issue of Diabetes. 3:45 After a quick rundown of our hosts' Halloween plans, this month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024! 5:00 Darleen and Kirk speak with Dr. Nicholas Maxwell, postdoctoral fellow at Duke University School of Medicine, and Claudia Grillo, a research associate professor in the Department of Pharmacology, Physiology, and Neuroscience at the University of Southern Carolina School of Medicine in Columbia. They are lead author and corresponding author, respectively, of the article "Leptin Activation of Dorsal Raphe Neurons Inhibits Feeding Behavior." This article is available for free at doi.org/10.2337/db24-0207. 27:05 Our hosts discuss the November issue's Paper of the Month, "Deciphering the Connection Between Microvascular Damage and Neurodegeneration in Early Diabetic Retinopathy." They're joined by senior author, Dr. Marcus Fruttiger, Professor of Experimental Ophthalmology at the Institue of Ophthalmology, University College, London. This study is available at doi.org/10.2337/db24-0107. 50:25 Finally, in honor of World Diabetes Awareness Day on November 14, as well as National Diabetes Month, this month's Sweet Talk segment features Dr. Giles Yeo, a geneticist and obesity researcher from the University of Cambridge. Dr. Yeo discusses how genetic variations contribute to obesity, appetite control, and metabolic health. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Grøndahl on glucagon clearance decrease in kidney disease despite preservation in liver cirrhosis, Barra and Russ on cryopreservation of stem cell–derived β-like cells, Sunilkumar and Dennis on targeting REDD1 to combat diabetes complications, & more! (00:51:16)
Welcome to the October 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the October 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:05 This month's episode begins with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code 'FALL24' at checkout. Act fast because this offer expires November 30, 2024! 5:15 Darleen and Kirk speak with Dr. Magnus Grøndahl, faculty of Health and Medical Sciences and doctor of medicine at University of Copenhagen, about his paper, "Glucagon Clearance Is Decreased in Chronic Kidney Disease but Preserved in Liver Cirrhosis." This article is available for free at doi.org/10.2337/db24-0305. 19:05 Our hosts discuss a featured article entitled "Cryopreservation of Stem Cell–Derived β-Like Cells Enriches for Insulin-Producing Cells With Improved Function." They're joined by the study's lead author, Dr. Jessie Barra, and corresponding author—as well as Barra's mentor—Dr. Holger Russ. This study is available at doi.org/10.2337/db24-0346. 35:00 Finally, just in time for National Vision Awareness Month, a Sweet Talk segment first: a discussion on the important topic of diabetic retinopathy. Dr. Siddharth Sunilkumar and Dr. Michael Dennis discuss their Perspectives article, "REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes," funded by the ADA Pathway to Stop Diabetes Initiator Award, which was given to Dr. Dennis in 2014. This article is freely accessible at doi.org/10.2337/dbi24-0013. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Jose Ortiz and Teresa Ku on trefoil factor 2 expression by pancreatic acinar cells, Adrian Vella on the effect of diabetes-associated variation in TCF7L2 on islet function, Matthew Webber on being a Pathway to Stop Diabetes awardee, and more! (01:02:27)
Welcome to the September 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the September 2024 issue of Diabetes and interview a Pathway to Stop Diabetes award winner. 4:20: Darleen and Kirk are joined by Jose A. Ortiz and Hsun Teresa Ku, first and last authors of "Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0490. 25:07: Kirk and Darleen talk to Adrian Vella, last author of "The Longitudinal Effect of Diabetes-Associated Variation in TCF7L2 on Islet Function in Humans." This article is also an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db24-0192. 50:21: In this month's Sweet Talk segment, Kevin chats with Matthew J. Webber, a 2019 Pathway to Stop Diabetes Accelerator Award winner, about his research on materials that can sense and respond to changing glucose. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Scientific Sessions Reviewed by ADA Podcast Co-Hosts! In this special episode, the co-hosts of DiabetesBio, Diabetes Care "On Air," Diabetes Core Update, and Diabetes Day by Day discuss highlights from the ADA's 2024 Scientific Sessions (00:54:39)
Welcome to a very special episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. While this podcast usually focuses on the research published in Diabetes, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Alice Cheng, MD, FRCPC, co-host of Diabetes Care "On Air," acted as emcee for a panel discussion with Michael Rickels, MD, MS, her co-host on Diabetes Care "On Air"; Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, the co-hosts of DiabetesBio; and Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care "On Air," DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer. This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions—the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways—across the "bench-to-bedside" spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.) Correction: •Dr. Carmella Evans-Molina is from the Indiana University School of Medicine •Dr. Lou Philipson is from the University of Chicago To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Inbal Caspi and Danwei Huangfu on glucose transporters in human glucostat, Deepthi Mallela discusses the genetics of bile acids and their association with diabetes, Bernard Thorens and David Hodson revisit a 1993 "Classic" on GLP-1, and more! (01:11:58)
Welcome to the August 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the August 2024 issue of Diabetes. 2:39: Darleen and Kirk are joined by Dr. Inbal Caspi and Dr. Danwei Huangfu, lead author and corresponding author, respectively, of the August Paper of the Month, entitled "Glucose Transporters Are Key Components of the Human Glucostat." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0508. 27:30: Kirk and Darleen host Dr. Deepthi P. Mallela, co-lead author of "Comprehensive Clinical and Genetic Analyses of Circulating Bile Acids and Their Associations With Diabetes and Its Indices." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0676. 50:21: In this month's Sweet Talk segment, Kevin and Kirk engage in a scintillating discussion with Dr. Bernard Thorens and Dr. David J. Hodson, coauthors of a recent "Classics in Diabetes" feature, named "Building the Glucagon-Like Peptide-1 Receptor Brick by Brick: Revisiting a 1993 Diabetes Classic by Thorens et al." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/dbi24-0025. The original "Classics" article is freely accessible at https://doi.org/10.2337/diab.42.11.1678. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Jordan Wright on the exocrine pancreas, Lisa Smeehuijzen on circulating monocytes for individuals with obesity and insulin resistance, Sweet Talk with this year's Banting Medal winner, Rury Holman, and more! (00:43:24)
Welcome to the July 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the July 2024 issue of Diabetes. 4:31: Darleen and Kirk are joined by Dr. Jordan J. Wright, first author of the Paper of the Month, entitled "Exocrine Pancreas in Type 1 and Type 2 Diabetes: Different Patterns of Fibrosis, Metaplasia, Angiopathy, and Adiposity." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0009. 17:23: Kirk and Darleen then chat with Dr. Lisa Smeehuijzen, first author of the article "Immunometabolic Signatures of Circulating Monocytes in Humans With Obesity and Insulin Resistance." This article is an editor-selected feature article and is freely accessible at https://doi.org/10.2337/db23-0970. 20:26: In a very special Sweet Talk segment, Kevin is joined by cohosts Darleen and Kirk for an interview with Dr. Rury R. Holman, the winner of the 2024 Banting Medal for Scientific Achievement. More details about this award can be found at https://professional.diabetes.org/awards/banting-medal-scientific-achievement-award. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
DeFronzo on a novel renal-hepatic axis in endogenous glucose production, arguments for and against the current model of glucose regulation of β-cell KATP channels from Rutter and Sweet (for) and Merrins and Kibbey (against), and more! (00:51:49)
Welcome to the June 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the June 2024 issue of Diabetes. 2:27: Darleen and Kirk are joined by Dr. Ralph A. DeFronzo, senior author of the article "Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2D and NGT Subjects." This article is freely accessible at https://doi.org/10.2337/db23-0457. 20:26: In this month's Sweet Talk segment, Kevin and Kirk highlight this month's Point-Counterpoint feature on whether a new model is needed on the regulation of β-cell KATP channels in glucose metabolism. First, they talk to Drs. Matthew J. Merrins and Richard G. Kibbey, authors of the Counterpoint, titled "Glucose Regulation of β-Cell KATP Channels: It Is Time for a New Model!" This article is freely accessible at https://doi.org/10.2337/dbi23-0032. 35:00: Kevin next is joined by Drs. Guy A. Rutter and Ian R. Sweet, authors of the Point article, titled "Glucose Regulation of β-Cell KATP Channels: Is a New Model Needed?" This article is freely accessible at https://doi.org/10.2337/dbi23-0031. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Devi Kasinathan, Zheng Guo, and Dax Fu on autoimmune diabetes, Jennifer Lee and Rebecca Salzo on WIN ADA, Olga Gupta and Rana Gupta on a "Classic" article about regional adiposity, and more! (00:53:36)
Welcome to the May 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the May 2024 issue of Diabetes. 5:06: Darleen and Kirk are joined by Drs. Devi Kasinathan, Zheng Guo, and Dax Fu, authors the May Paper of the Month, "Cell-Surface ZnT8 Antibody Prevents and Reverses Autoimmune Diabetes in Mice." This article can be freely accessed at https://doi.org/10.2337/db23-0568. 20:14: Next, Kirk and Darleen highlight one of the ADA's membership engagement groups, the Women's Interprofessional Network of the ADA (WIN ADA), by chatting with Drs. Jennifer Lee and Rebecca Scalzo, the current cochairs of WIN ADA. They discuss the history and growth of WIN ADA, which is a members-only network for female clinicians, scientists, educators, and other health professionals in diabetes. Learn more about WIN ADA, including how to join, at https://professional.diabetes.org/membership/win-ada. 36:45: For the Sweet Talk segment, Kevin is joined by Drs. Olga T. Gupta and Rana K. Gupta, authors of May's "Classics in Diabetes" article. The classic article they focus on is 1985's "The Influence of Body Fat Distribution on the Incidence of Diabetes Mellitus: 13.5 Years of Follow-up of the Participants in the Study of Men Born in 1913," by Ohlson et al. Kevin and his guests discuss the evolving concepts of regional adiposity and diabetes and other chronic disorders. Their "Classics" article is freely available at https://doi.org/10.2337/dbi24-0021, and the 1985 classic by Ohlson et al. can be found at https://doi.org/10.2337/diab.34.10.1055. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Sebastian Kalamajski on genetic aspects of adiposity-related traits; Yuval Dor on DNA methylation–based assessment of pancreas and islet cells; and Carmella Evans-Molina on the role of calcium in regulating insulin secretion. (00:59:57)
Welcome to the April 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the April 2024 issue of Diabetes. 2:55: To kick things off, Darleen and Kirk are joined by Dr. Sebastian Kalamajski (Lund University), senior author of "Human Genetic Variation at rs10071329 Correlates With Adiposity-Related Traits, Modulates PPARGC1B Expression, and Alters Brown Adipocyte Function." This article can be freely accessed at https://doi.org/10.2337/db23-0531. 15:16: Darleen and Kirk chat with Dr. Yuval Dor (The Hebrew University of Jerusalem), senior author of "DNA Methylation–Based Assessment of Cell Composition in Human Pancreas and Islets." This study can be freely accessed at https://doi.org/10.2337/db23-0704. 42:50: Darleen introduces a very special guest for this month's Sweet Talk, Dr. Carmella Evans-Molina. She is the director of the Center for Diabetes and Metabolic Diseases at Indiana University School of Medicine, and she was awarded the 2023 Outstanding Scientific Achievement Award by the American Diabetes Association. Darleen and Kevin raise many topics in this conversation with Dr. Evans-Molina, from her focus on the role of calcium in regulating insulin secretion to the importance of serendipity and collaboration in scientific research to her recent hobby of learning to play the piano. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Bonus Sweet Talk episode with Christopher Newgard and Louis Philipson about the ADA's Pathway to Stop Diabetes initiative, Céline E. Riera on her Pathway award-winning research, and more! (00:41:15)
Welcome to the special Sweet Talk March 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. Our host is Dr. Kevin Williams. 1:00 Sweet Talk, part 1. Kevin introduces the guests for the first part of Sweet Talk, Dr. Christopher Newgard from Duke University Medical Center and Dr. Louis Philipson from the University of Chicago School of Medicine. They are co-chairs of the American Diabetes Association's Pathway to Stop Diabetes Mentor Advisory Group. The Pathway program seeks to identify and support exceptional young scientists in the field of diabetes research. Drs. Newgard and Philipson explain the history of the program, expand on the importance of mentorship for young scientists, and relate challenges faced by the program, from funding cuts to the COVID-19 pandemic. 18:56 Sweet Talk, part 2. To wrap up the episode, Kevin brings in Dr. Céline E. Riera, recipient of a Pathway to Stop Diabetes initiator award in 2015. Dr. Riera is the author of a thought-provoking Perspective article in the March 2024 issue of Diabetes that is based on her award-winning research. This article can be freely accessed at https://doi.org/10.2337/db23-0706. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
Harry Cutler and David James on using a dual tracer test to identify insulin resistance in mice, Lori Sussel on PTPN2 regulation of metabolic flux, a preview of a special Sweet Talk episode this month, and more! (00:40:24)
Welcome to the March 2024 episode of DiabetesBio—the American Diabetes Association's podcast for its flagship research publication, Diabetes. In this episode of DiabetesBio, Drs. Kirk Habegger, Darleen Sandoval, and Kevin Williams discuss the latest and greatest content in the March 2024 issue of Diabetes. 1:15 Before getting underway with this week's interviews, Kirk gives a quick shout-out to March's Paper of the Month: "High Doses of Exogenous Glucagon Stimulate Insulin Secretion and Reduce Insulin Clearance in Healthy Humans," by Gray et al. Although they only mention it in passing, Kirk does offer a ringing endorsement: "It's excellent work, and all things glucagon are good." This article is freely available at https://doi.org/10.2337/db23-0201. 2:44 Darleen announces that the March DiabetesBio is actually two episodes. The first part features Darleen and Kirk interviewing authors of the feature articles of the month, and the second part is devoted to Sweet Talk with Kevin. In this special episode, Kevin delves into the ADA's Pathway to Stop Diabetes initiative with two of the initiative's key members and one of the initiative's award-winning researchers. 4:30 Darleen and Kirk interview Mr. Harry B. Cutler and Dr. David E. James, first and last authors of "Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia." They discuss the use of a dual tracer test and describe insights into tissue-specific insulin action. They also raise an interesting question: Could it be that the popular belief that peripheral insulin resistance leads to hyperinsulinemia is inaccurate? This article can be freely accessed at https://doi.org/10.2337/db23-0035. 27:50 Kirk and Darleen then host Dr. Lori Sussel, last author of "PTPN2 Regulates Metabolic Flux to Affect β-Cell Susceptibility to Inflammatory Stress." Dr. Sussel and her group determined that β-cells lacking PTPN2 are more susceptible to inflammatory stress associated with T1D due to impaired glucose-stimulated insulin secretion, mitochondrial defects, and reduced glucose-induced metabolic flux, indicating a role for PTPN2 in maintaining metabolic fitness in β-cells. This article can be freely accessed at https://doi.org/10.2337/db23-0355. To learn more about Diabetes and DiabetesBio, please visit diabetesjournals.org/diabetes. Thank you for listening, and don't forget to smash that "follow" button!
