The Duke Clinical Research Institute is drawing on gold-standard research and real-world evidence to bring you Beyond the Endpoint, a podcast that is demystifying clinical research and healthcare through conversations with renowned clinicians and scientists.
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From Innovation to Implementation: AI in Action (00:26:24)
Guests Michael Pencina and Suresh Balu join the Beyond the Endpoint hosts to explore the impact of AI in healthcare. They discuss the role of AI-powered tools in research, clinical care, and operation...
Beyond the Headlines Series: Looking back at 2025 headlines, Dementia & Vaccines, and Cannabis Research (00:20:40)
Kick off 2026 with hosts Manesh Patel and Emily O'Brien as they evaluate last year's most discussed health stories and wellness trends, cannabis reclassification, and a shingles vaccine-dementia study...
Behind the Voices: Get to Know Emily & Manesh (00:28:25)
Hosts Manesh Patel and Emily O'Brien share their amusing and inspiring personal and professional trajectories, exploring how mentors shaped their paths in clinical research, why asking unconventional ...
From Provider to Patient: A Dual Perspective on Colorectal Cancer (00:38:40)
Hosts Emily O’Brien and Manesh Patel sit down with Dr. Ajay Kohli and Dr. Julius Wilder for a dual-perspective conversation on colorectal cancer, where they discuss personal experiences, the importanc...
Beyond the Headlines: Recap of the 2025 AHA Scientific Sessions (00:20:42)
Recorded at the 2025 American Heart Association Scientific Sessions, hosts Manesh Patel and Emily O'Brien discuss late-breaking cardiovascular research, including gene-editing therapy for cholesterol,...
Connecting the Dots: The Broader Applications of GLP-1s and Where We’re Headed Next (00:36:41)
Endocrinologist Jennifer Green discusses how GLP-1 drugs, like Ozempic, evolved from diabetes tools to potential treatments for addiction and heart disease, in this final installment of the obesity se...
Obesity, GLP-1s, and the Evidence: What the Data Tells Us (00:31:04)
In this second episode of our obesity series, preventive cardiologist Neha Pagidipati sheds light on the discovery, impact, and uses of GLP-1s, like Ozempic and Mounjaro. Learn about the impact these ...
It's Not Just the Scale: Supporting Sustainable Change in Obesity Treatment (00:32:14)
In the first of a three-part series on obesity and GLP-1 medications, our guest Jennifer Norris shares the evolving landscape of obesity treatment. The conversation addresses common misconceptions and...
Beyond the Headlines: Funding Research, Vaccines, Sleep Health, and AI in Healthcare (00:26:43)
The "Beyond the Headlines" series returns with summer healthcare and research news. Hosts Manesh Patel and Emily O'Brien discuss misconceptions about research funding, a Danish study on vaccine safety...
Understanding Autism: Insights from Research and Practice (00:26:02)
Ushering in the second season of Beyond the Endpoint, Lauren Franz, MBChB, MPH, interim director of the Duke Center for Autism and Brain Development, joins Manesh Patel and Emily O'Brien for an in-dep...
Playing to Advance Care: A Championship Mindset in Clinical Research (00:34:35)
What do championship sports teams and successful research institutions have in common?
In the season finale of Beyond the Endpoint, Dr. Adrian Hernandez joins hosts Manesh Patel and Emily O’Brien to...
Beyond the Headlines: Protein myths. Anti-aging hype. Autism research. A new diabetes drug? (00:24:53)
In this new episode of the Beyond the Endpoint series, “Beyond the Headlines,” hosts Emily O’Brien and Manesh Patel break down what’s you should know about these trending medical topics.
From hype t...
Stepping Up: From Curiosity to Confidence — What to Know Before You Join a Trial (00:24:41)
Why do people volunteer for clinical trials — and what should they know before doing so?
In this episode of Beyond The Endpoint, we explore common questions, reasons, and myths about clinical trial ...
Stepping Up: Why Participate in Clinical Research? (00:32:13)
In this episode, cancer survivor Katie Ortman-Doble opens up about her journey through clinical research and why she chose to participate. Hosts Emily O’Brien and Manesh Patel, joined by Jenny Cook, t...
Bridging Science and Policy: A Conversation with Dr. Robert Califf (00:31:07)
In this episode of Beyond the Endpoint, former FDA commissioner Dr. Robert Califf joins hosts Manesh Patel and Emily O’Brien to discuss critical challenges shaping the future of patient care. From mis...
Beyond the Headlines: What’s trending in medical news? (00:25:52)
Ozempic curbing alcohol cravings, ADHD linked to shorter life expectancy, and an NBA rising star diagnosed with DVT—what does the science actually say? In this first episode of Beyond the Headlines, a...
Wearables in Clinical Research: Data, Trends, and Challenges (00:35:31)
Smartwatches, fitness trackers, and health data—how are wearables reshaping clinical research? In this episode, Dr. Marat Fudim joins us for an insightful discussion on how wearable technology is shap...
The Intersection of Politics and Medicine: Impacts on Clinical Practice (00:32:37)
In this episode of Beyond the Endpoint, Emily O’Brien and Manesh Patel sit down with Leslie Curtis, former senior FDA policy advisor, to explore the FDA’s role in balancing science, public health, and...
Bending the Curve on Hypertension (00:34:18)
Reducing hypertension risk isn’t just about cutting salt. This week on Beyond The Endpoint, Emily O’Brien, Manesh Patel, and Jenny Cook talk with Dr. Dhruv Kazi about the complex public health battle ...
Caring Through Loss: The Role of Grief in Clinical Settings (00:34:56)
In this episode of "Beyond the Endpoint," hosts Emily O'Brien and Manesh Patel are joined by guest host Jenny Cook to discuss grief among healthcare providers with Tony Galanos, a researcher and physi...
Inviting Our Colleagues To Participate In DCRI On Record (00:04:58)
Inviting Our Colleagues To Participate In DCRI On Record by Duke Clinical Research Institute
John Shepherd And Michele Nolen (00:03:44)
John Shepherd And Michele Nolen by Duke Clinical Research Institute
Assessing Results of Open-label, Comparative Effectiveness Trials for Cardio-metabolic Drugs (00:17:03)
Assessing Results of Open-label, Comparative Effectiveness Trials for Cardio-metabolic Drugs by Duke Clinical Research Institute
Duke IBD Podcast Series: IBD and Nutrition (00:14:55)
Duke IBD Podcast Series: IBD and Nutrition by Duke Clinical Research Institute
IBD Podcast with Dr. Jane Onken (00:23:44)
IBD Podcast with Dr. Jane Onken by Duke Clinical Research Institute